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Participants (N=3417) were randomly assigned (21:3:3:7) to receive the combination of semaglutide 2.4 mg and cagrilintide 2.4 mg (n=2108), semaglutide 2.4 mg alone (n=302), cagrilintide 2.4 mg alone (n=302), or placebo (n=705), plus lifestyle interventions for all groups

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Though melatonin is known as a hormone that helps synchronize sleep-wake cycles, it has also been shown to be produced in the digestive tract in quantities far larger than in the brain (Bubenik 2002)