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The potential clinical implications of these observations have been confirmed by a recent multicenter trial involving over 4000 patients, in which dulaglutide resulted in approximately a 14% reduction in the risk of cognitive decline after 5 years of therapy [22]

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However, it was revealed that the increase in dROMs value of the Si-DSS group, was significantly alleviated from the 3rd day after DSS administration as compared with the Con-DSS group

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