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discovered that the amino acid content in radiation-resistant HepG2 cells significantly increased under iron death stress

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[] While many anti-oxidants are active either in lipid or aqueous phases, LA is active both in lipid and aqueous phases

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In contrast to other cell death mechanisms, such as apoptosis or necrosis, ferroptosis is predominantly caused by failure of the cellular antioxidant systems, particularly the enzyme glutathione peroxidase 4 (GPX4) (21,22)

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This increases oxidative stress and causes damage, which your liver has to handle

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