Topical methimazole, although not allowed in cosmetics, did not induce melanotoxicity or changes in thyroid functions [78, 98], and was proven to be a useful alternative treatment in some melasma cases [97]
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30 YangH.ChenC.ChenH.DuanX.LiJ.ZhouY.et al (2020)
Summary Keywords thiamine, gastrointestinal beriberi, acetylcholine, intestinal ThDP-dependent enzymes, intestinal transport of thiamine, intestinal metabolism of thiamine, functional gastrointestinal disorder Citation Overton E, Emelyanova A and Bunik VI (2025) Thiamine, gastrointestinal beriberi and acetylcholine signaling
These are starting recommendations
Research indicates that oral delivery of DSIP is not as effective due to its structure and absorption properties