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High cortisol levels can increase sugar cravings, elevate blood sugar, and encourage fat storage, particularly in the abdominal region
This information is provided for educational purposes only and is not intended to diagnose, treat, or prevent any medical condition
Physicians assess medical history, current medications, and contraindications before prescribing
RoB2 examines 5 domains to evaluate the risk of bias in each RCT, whereas ROBINS-I evaluates observational studies in 7 domains to determine the risk of bias as low, some, or high concern
Published in NEJM in 2022, SURMOUNT-1 randomized 2,539 adults with obesity (BMI 30) or overweight (BMI 27) with weight-related conditions, without diabetes, to tirzepatide 5mg, 10mg, 15mg, or placebo, alongside diet and exercise