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Of the five explanations above for why the evolutionary transsulfuration pathway flux-reversal is advantageous for heterotrophs, the last option, Signaling , is the easiest to correlate to unique metazoan needs, and might be the most important attribute that offset potentially detrimental consequences of being Met-auxotrophic

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This is the central tension around the compound: a powerful, replicable signal in rodents and emerging human anecdotal data, paired with a lack of large randomized controlled trials