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In addition, the proximity between the ECD and the TM domain limits the accessibility of an antibody for binding to the ECD

The integration of these computational approaches is reshaping the landscape of drug discovery in Chinese medicine and advancing the development of more effective antidepressant therapies

J Cell Mol Med, 2017

The GHR is a challenging target in this regard in that it lacks a kinase domain and the ligand binding surface involves a large, relatively featureless protein-protein interface

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