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While these medications do not directly cause hypothyroidism, significant weight loss can sometimes unmask subclinical thyroid disease or necessitate adjustment of thyroid hormone replacement in patients with pre-existing hypothyroidism

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Zepbound (tirzepatide) acts as a "dual agonist," targeting both GIP and GLP-1 pathways

A definitive CART receptor has as yet not been isolated

Researchers who have explored peptide therapy options through clinical settings often find that supervised protocols use similar conservative escalation approaches

LY3437943 demonstrated a safety and tolerability profile equivalent to other incretins in a phase 1 single ascending dosage study