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Understanding the broad mechanism of action is essential when considering whether GLP-1 medications might influence hormonal balance more generally, particularly given their increasing use in diverse patient populations including those with metabolic syndrome, polycystic ovary syndrome (PCOS), and obesity-related endocrine dysfunction

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Similarly, a meta-analysis of nine observational studies in older adults found low serum vitamin B 12 concentration to be associated with increased risk for depression, with significant association only in women (100)