91 QuinnC
Liposomes, capable of encapsulating both hydrophilic and hydrophobic drugs, offer dual and multitargeting capabilities [214, 215]
[DOI] [PubMed] [Google Scholar] 80.Meeran K, O'Shea D, Edwards CM, Turton MD, Heath MM, Gunn I, Abusnana S, Rossi M, Small CJ
KL1 was washed off before infection, indicating host-targeted adjuvant activity
It downregulates mitochondrial membrane potential, causing pro-apoptotic factors such as Bax, Bid, and Bak to bind to the mitochondrial membrane, disrupt it, release Cytc, and activate Caspase-9, which then activates Caspase-3, inducing cell death (148)
Generally, maintaining at least 72 hours between doses is the minimum safe interval for weekly injections, though aiming for as close to seven days as possible remains ideal