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According to StatPearls (NCBI Bookshelf), the most common adverse effect of intramuscular vitamin B12 injections is significant pain at the injection site, which is particularly noted in thinner individuals

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People dealing with gastric ulcers, GI inflammation, or gut barrier disruption are among those who seek it out

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Pick the right kind of vitamin B12 There are two most common forms of vitamin B12: cyanocobalamin and methylcobalamin