The very rigid, stable structure of catalases is resistant to unfolding, which makes them uniquely stable enzymes that are more resistant to pH, thermal denaturation and proteolysis than most other enzymes
Moreover, they can be modified to express targeting ligands on their surface, enabling specific delivery to target cells or tissues and enhancing the therapeutic efficacy while reducing off-target effects of the delivered molecules [121, 220]
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236 The circadian control of intracellular NAD + levels by the clock is attributed to the oscillation expression of NAMPT, a rate-limiting enzyme in the salvage of NAD + with a 24-hour rhythm
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They tend to have reduced bone repair and increased fracture risk, presenting a treatment challenge
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