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Overall, estrous phase explained 17.8% of the variance in semaglutide-induced weight loss, a highly significant effect size on par with genetic background or disease comorbidity 67

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People were able to maintain approximately 10% WL over a 4-year period, and the proportion of participants experiencing SAE during the trial was lower in those assigned to semaglutide 2.4 mg compared to placebo (33.4% vs