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International journal of clinical and experimental pathology
A) Once-daily long-acting insulin glargine (typically given at bedtime) achieves a steady-state within ~2 hours, does not display a distinct peak, and has a 20-24 hour duration of action in most patients
That said, research is clear that weight regain is common after stopping GLP-1 medications
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It elevates cortisol, promotes insulin resistance, and impairs decision-making around food
Others rely heavily on compounded medications and offer minimal follow-up
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