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More serious but rare adverse effects include pancreatitis, gallbladder disease, hypoglycemia (when used with insulin or sulfonylureas), acute kidney injury (particularly with dehydration), and hypersensitivity reactions including anaphylaxis

Anderson KM, Ferranti EP, Alagha EC, Mykityshyn E, French CE, et al

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They occur because your body adapts to a new calorie intake level and may require small dose adjustments or lifestyle modifications to break through

Ongoing and future clinical studies are expected to provide deeper insights into its mechanisms of action and expand its therapeutic applications