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While GLP-1RAs effectively improve glycemic control and cause weight loss, potential safety concerns have arisen over the years

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Even though there usually is remarkable variability in individual capacity for weight loss in response to pharmacological agents [36], these results might suggest that patients with poor metabolic long-term outcomes following BS are less likely to benefit from add-on pharmacotherapy

And once you start digging into it, you realize its less about size or strengthand more about how it interacts with specific systems