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As to the pi class, GSTP1-1 point mutations in both exon 5 (codon 105) and exon 6 (codon 114) were observed and shown to have an impact on the enzymatic activity 32

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Whether alternative pathways such as thioredoxins 90 or other members of the redox hub such as ascorbate 44 might be involved in the process also remains to be elucidated

Interestingly, it can be noted that whereas NEM pre-treatment was a common feature in the first clinical studies, more recently this use was pretty abandoned

Infection and Immunometabolism in the Central Nervous System: A Possible Mechanistic Link between Metabolic Imbalance and Dementia