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Conversely, no significant differences in type 2 inflammatory markers were observed between treatment with a GLP-1R/GIPR dual agonist and single GLP-1R or GIPR agonists [189]

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Persistent or worsening symptoms despite dietary modifications and over-the-counter interventions lasting more than 2-3 weeks should be discussed with your prescribing clinician, as this may indicate inadequate tolerance to the current dose or the need for alternative management strategies

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