Giza, L
FDA is accepting feedback until 9 October
In the retatrutide trials, the ratio of fat loss to lean loss was favorable compared to caloric restriction alone, where lean mass can represent 25-35% of total weight lost
Combining with other weight loss agents Tesofensine + GLP-1 agonists (theoretical): Different mechanisms = potential synergy Tesofensine: Metabolic + CNS appetite GLP-1s : Strong appetite + gastric slowing Could enhance weight loss to 20-25%+ BUT: No clinical data, significant risks Not recommended without supervision Potential combination benefits: Address multiple pathways Overcome plateaus Better than either alone (theoretically) Metabolic boost + strong appetite suppression Maximum fat loss Combination risks: Compounded cardiovascular strain Unknown drug interactions Excessive weight loss risks Cost ($1,500-2,000/month) Safer alternatives to tesofensine combinations: Tirzepatide alone (15-22% loss, FDA approved) CagriSema (sema + cagrilintide, 15-25%) GLP-1 + lifestyle (safer, proven) Learn about peptide stacking strategies at SeekPeptides
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Before surgery, it is best to use decompressive therapy: garments, lymphatic massage and lymph-press to remove as much fluid from the extremities
