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The compound is a cyclic lactam analogue of -MSH that has an amino sequence named MTII (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2)

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A 2011 in vivo study demonstrated that, in this mouse model, the administration of Pioglitazone induces a proadipogenic antitumor response, with the final result of preventing metastasis and reducing tumor size (Zhang et al., 2017) highlighting the importance of the use of this compound in that specific clinical setting

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Biochimie 84 : 975980 Albert SG and Mooradian AD (2004) Low-dose recombinant human growth hormone as adjuvant therapy to lifestyle modifications in the management of obesity

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