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Pohl S-G, Brook N, Agostino M, Arfuso F, Kumar AP, Dharmarajan A

Liver/Kidney/CYP450: High-dose systemic copper chelate therapy requires strict monitoring of ceruloplasmin and unbound serum copper to prevent heavy metal toxicity or Wilson-like hepatic accumulation

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And the formulation that carried GHK-Cu into controlled human testing under a pharmaceutical generic name was a topical gel , not an injection the one time the compound was developed with regulatory intent, the route chosen was the skin