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Abstract Plasmodium falciparum parasites are increasingly drug-resistant, requiring the search for novel antimalarials with distinct modes of action

berghei GFP-Luc ama 1 (1037cl1) parasite line was used to assess antiplasmodial activity of ChemBridge Hit2Lead library compounds (CB compounds) and the half-maximal effective concentration (EC 50 ) by in vitro drug luminescence assay as previously described (Lin et al., 2013)

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Macropinocytosis Macropinocytosis, a nutrient-scavenging pathway, is a compensatory route that supplies amino acids to nutrient-starved cancer cells harboring oncogenic mutations in KRAS or PTEN 118,119,120

J., Douglas, R

"It's not about sleeping less It's about getting a higher quality of sleep and having more resilience." To achieve the best sleep possible, he blacks out his room with curtains that don't let street lights in