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5 Potential pathophysiological mechanisms of toll-like receptors and gut bacterial translocation in schizophrenia and psychiatric disorders Toll-like receptors (TLRs) coordinate the activation of innate immune responses alongside the complement system and play a significant role in the neuroimmune mechanisms of schizophrenia

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The downside to this was that only about 15-20% of it was absorbed through the digestive tract

However, bioavailability through topical application remains limited compared to injectable delivery

No published human study tracks continuous use beyond 12 weeks, making extended unsupervised administration an undocumented risk with the current state of evidence on BPC-157