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21-3.32 for non-cardia GC)

If more than 48 hours have passed, skip the missed dose

The largest trial of ERAs, SONAR, including 2648 participants with type 2 diabetes and proteinuric CKD, demonstrated that atrasentan on top of RAS inhibition significantly lowered the risk of a doubling of serum creatinine or ESKD compared with placebo by 35% [75]

If nausea is an issue, focus on smaller, more frequent meals instead of large portions

Smoking compounds these effects by restricting circulation and promoting inflammation, which accelerates neuropathy progression