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These amino acid alterations in sPE illustrate the intricate interplay between oxidative stress, inflammation, and endothelial dysfunction, providing valuable insights into the diseases pathophysiology

Oxidative stress and TGF-1 produce chronic kidney damage, leading to kidney fibrosis (8, 146148)

Meade TW, Greenberg G, Thompson SG

[26] A complication of severe chronic PA is subacute combined degeneration of spinal cord, which leads to distal sensory loss (posterior column), absent ankle reflex, increased knee reflex response, and extensor plantar reflex response

doi: 10.1038/s41392-020-00374-6 3 Abdool KarimS