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Conversely, the importance of inhibiting ferroptosis in surrounding healthy cells cannot be overstated

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i , Representative fluorescent micrographs of intestinal nuclear permeability in wild-type, cco-1 RNAi, or fer-2 (5 mM) supplementation animals injected with 70 kD dextran in the cytosol and corresponding fluorescence intensity distribution curve

In addition, we assessed the effect of sulfasalazine in unilateral ureteral obstruction (UUO) model, another established model of the formation of TLS in the kidney (Supplemental Figure 9A)

This underscores the uncertainty surrounding the long-term effects of these agents, which patients may need to take indefinitely to sustain weight loss