As the key technology behind #Rybelsus (oral #semaglutide), SNAC temporarily increases the local gastric pH, protecting GLP-1 from enzymatic degradation and enabling direct absorption through the gastric lining into systemic circulation
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These include sheep thyroid extract, amphetamine, diuretics, laxatives, fenfluramine/phentermine, and sibutramine [12]
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Yes, continuous, long-term administration can lead to pituitary receptor desensitization, reducing the effectiveness of the peptides
The remaining authors declare no competing interests