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It is manufactured by Eli Lilly and Company

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It is unknown whether ZEPBOUND causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as the human relevance of tirzepatide-induced rodent thyroid C-cell tumors has not been determined (5.1, 13.1)

Dehydration is the primary culpritappetite suppression can reduce daily fluid intake by 30-40%, while nausea may further limit hydration during the initial adjustment period

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