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General principles for restarting GLP-1 medications include: Adequate oral intake : You should be tolerating a normal diet (or your usual post-operative diet plan) without significant nausea or vomiting Resolution of post-operative ileus : Normal bowel function should have returned, particularly after abdominal or pelvic surgery Stable clinical condition : Any post-operative complications should be resolved, and you should be recovering as expected Medical team approval : Always confirm with your surgical team or GP before restarting If you've been off a GLP-1 medication for several weeks, your doctor may recommend re-titrating the dose (starting at a lower dose and gradually increasing) to minimise gastrointestinal side effects when restarting