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10.3390/ijms22147491 209 Molina-SotomayorE.Castillo-QuezadaH.Martnez-SalazarC.Gonzlez-OrbM.Espinoza-SalinasA.Gonzalez-JuradoJ

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When neurological symptoms are present, more intensive treatment is required: 1 mg hydroxocobalamin on alternate days until no further improvement occurs, followed by maintenance therapy every two months

Scherzinger E, Lurz R, Turmaine M, Mangiarini L, Hollenbach B, Hasenbank R, Bates GP, Davies SW, Lehrach H, Wanker EE

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Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial