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It works by mimicking two naturally occurring hormones, GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), which play essential roles in regulating appetite and metabolizing glucose

However, because both can affect the gastrointestinal system, your doctor should be aware of this combination to monitor for any signs of stomach irritation or bleeding

Accessed 7 May 2019

The pathway there goes via Taco Bell, actually, at the end

Most patients notice appetite suppression within the first few weeks

This is a composite, and individual results vary widely but it captures a pattern I now see often enough that I ask about metabolic inflammation at nearly every RA visit