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There are a whole class of medications that are insulin sensitizers, so perhaps we can develop medications that will allow people to be sensitized to GLP-1s or find formulations of GLP-1, like the longer-acting versions, that avoid the GLP-1 resistance. Anna Gloyn A key function of GLP-1 and drugs that mimic it is to slow the passage of food through the stomach, known as gastric emptying, which helps with both glucose regulation and weight loss

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GLP-1s can reduce thirst along with hunger, so patients forget to hydrate and then constipation shows up uninvited