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Most clinical studies use 500 mg to 1000 mg dosages, taken regularly for at least 8 weeks

The concern is not that the anti-acne effects cancel out, they likely add up, but that pharmacodynamic overlap means the body is receiving redundant pressure on sebocytes and hepatic detoxification pathways simultaneously

Their popularity reflects a broader wellness trend rather than a sudden increase in B12 deficiency diagnoses among the general population

The pooled prevalence of PSE in this cohort was 0.133 (95% CI = 0.048, 0.247)

doi:10.1155/2012/324832 Pickart L, Margolina A

Maintaining healthy levels of B12 in the body prevents anemia