Early Discoveries, With More to Come So far, GLP-1s, first approved 20 years ago for type 2 diabetes and later obesity, have shown potential in treating a surprisingly wide range of conditions, such as heart disease, Parkinsons, Alzheimers, sleep apnea, and liver disease
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GLP-1 and the NVU GLP-1 receptors are expressed on various cell types within the NVU, including neurons, astrocytes, microglia, and endothelial cells
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Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure
