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Discussion Here we report the development of a unimolecular quintuple agonist that combines the body weight and blood glucose-lowering effects of GLP-1GIP co-agonism with the insulin-sensitizing and anti-inflammatory properties of the nuclear-acting PPAR// triple agonist Lani through targeted delivery into cells expressing GLP-1R and/or GIPR

Doses as high as 2 mg (2,000 g) daily by mouth or 1 mg monthly by intramuscular (IM) injection have been used to treat pernicious anemia without significant side effects (136)

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