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The postsynaptic side plasticity Although tracking presynaptic structures identifies changes in putative inhibitory synaptic contacts the fluorescent tagging of the scaffolding protein gephyrin allows dynamic visualization of the postsynaptic component of GABAergic synapses (Figure 3)

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Your healthcare team may suggest starting at the lowest dose and progressing more slowly than the standard titration schedule if your IBS is particularly severe or poorly controlled

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Eckenroth et al., 2006