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Quick Answer: GLP-1 agonists show preliminary promise for binge eating disorder but lack FDA approval and robust clinical trial evidence for this indication

Mechanistically, there is no established biological pathway by which semaglutide would directly damage pancreatic tissue

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While data from a RCT controls for many of the potential confounding factors, using data from non-primary endpoints requires caveats

Some may even contain toxic ingredients, such as chromium, which is not approved for weight reduction