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1 Introduction According to the International Diabetes Federation, the global population with diabetes reached 537 million by 2021, with 90% of cases attributed to type 2 diabetes (T2DM) (Ahmad et al., 2022)

Patients should be informed of dietary modifications that could help reduce symptoms such as smaller portion sizes and avoiding fatty foods [49]

Were there any differences compared to other incretin therapies

Pairing Ipamorelin with the multi-day DAC form would mismatch the timescales: a transient ghrelin-receptor pulse riding on top of a persistently elevated GHRH baseline that sits high for days, so the intended pulse-on-pulse synergy is lost