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It is usually considered for patients who have reached their goals and prefer to trial life off medication, those with ongoing intolerance, new contraindications, pregnancy plans, access or cost barriers, or a change in clinical priorities

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The peptide releases directly into the gastric environment where it can exert local protective effects before degradation occurs

However, when the 12-month data were analyzed, and the decision taken to move up to 3.0 mg, the non-uniform time for dose-switch from liraglutide 2.4 to 3.0 mg during year 2 (as a result of differences in local ethical committee efficiency) is also a limitation

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