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This is significant because leptin has its primary effects in the brain but does not cross the blood-brain barrier as readily as MT-2

Drogat, B

This changes how fast you digest food

The first stage is Trem2-independent and involves a reduction in homeostatic microglia checkpoint genes such as Cx3cr1, P2ry12 , and P2ry13 , along with upregulation of genes including the Trem2-signaling adaptor Tyrobp, Apoe , and B2m

Cerebellar networks with the cerebral cortex and basal ganglia