It is essential for the function of macrophages, the cells responsible for clearing away spent neutrophils before they can undergo NETosis
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2017;10:1179064417696070 Townsend DM, Pazoles CJ, Tew KD
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Notably, in some experiments, low-dose application of MO might have a better anti-inflammatory effect than higher doses ( FIGURE 1 Research evidence has demonstrated the therapeutic value of MO to treat immune disorders
In contrast, persistently stabilized NRF2 in response to KEAP1 or NRF2 mutations causes sustained activation of these genes, leading to the accumulation of xCT/SLC7A11, GCLC, and GCLM that cause a depletion of intracellular glutamate (Sayin et al