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Research shows that patients on chronic corticosteroids experience slower weight loss with GLP-1 therapy, but many still achieve meaningful results when doses are optimized

Cell Metabolism, 21 (3), 443-454

Malatt C, Wu T, Bresee C, Hogg E, Wertheimer J, Tan E, et al

Consequently, -cell resilience to inflammatory and metabolic stressors declines, -cell death accelerates, and the functional reserve of the islet compartment progressively deteriorates

[22] [23] Pioglitazone , a diabetes medication, has also shown benefit in some patients with biopsy-proven NASH, but its use should be specialist-supervised and limited to selected cases