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For the treatment of non-metastatic castration-resistant and metastatic castration-sensitive prostate cancer, clinical guidelines recommend androgen receptor antagonists, such as apalutamide, in combination with androgen-deprivation therapy as the standard of care

doi: 10.1111/anae.16454

Unfortunately, currently available drug options become less effective with long-term use and have dose-limiting side effects and/or poor efficacy

So the picture is hopeful but far from settled

Discussion This work shows that sucrose feeding decreases GSH concentration and causes a consequent oxidative stress and insulin resistance in SF animals and that glycine supplemented to diet increases GSH biosynthesis, reduces oxidative stress, and improves insulin sensitivity and insulin cell signaling in liver from SF rats