Trial data consistently show that patients who rush escalation have more nausea and vomiting, while those who stay on each step for the full month tolerate the drug better
63, 640648.10.1046/j.1471-4159.1994.63020640.x 11 BauerP
Given that tirzepatide is a relatively new therapy, prescribing patterns and patient characteristics may have evolved over the study period
Good matching with the time series observed experimentally and in other models can only be obtained if the underlying model has a sufficient level of detail, uses relevant kinetic data for initial parameterization, and employs applicable constraints (e.g., a physiological range of metabolite concentrations and a typical range of values for kinetic parameters of a given type)
Degroote L, Martens PJ, Viaene M et al (2025) Verapamil and low-dose anti-mouse thymocyte globulin combination therapy stably reverses recent-onset type 1 diabetes in NOD mice by acting on the beta cell and immune axes
On the other hand, side effects related to stopping, such as increased hunger, food cravings and the return of food noise, may begin before the medication has fully cleared and can persist unless other weight-management strategies are in place