Therefore, both chronic and acute sodium depletion, whether induced by diuretics or other medications, such as antidiabetic SGLTs inhibitors (Koh et al., 2023), may contribute to the worsening of metabolic disturbances
GLP-1 and GIP receptor agonists seem to have a synergistic effect in weight reduction, although the mechanism is not yet clear [44]
In CKD Jardiance is used to reduce the risk of sustained decline in estimated glomerular filtration rate (eGFR), end-stage kidney disease, cardiovascular death and hospitalization
Strive is suing Eli Lilly, which makes Trulicity and other types of GLP-1s, for allegedly blocking drug companies from making cheaper, customized generic drugs
Importantly, when used exclusively for weight management, GLP-1 RAs showed no association with preterm birth (liraglutide, n = 194: aOR 1.01, 95% CI 0.581.76
Treatment guidelines focus on nutrition, exercise, and pharmacologic therapies to prevent and manage complications