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This activates the Keap1-Nrf2 pathway and upregulates antioxidant enzymes to promote metabolic inactivation of APAP

This pathway, involving key enzymes such as glutamate-cysteine ligase (GCLC), glutathione peroxidases (GPXs), glutathione reductase (GSR), and glutathione S-transferases (GSTs), is crucial for maintaining redox balance, thereby supporting tissue repair and regeneration 5

Cell 163 , 3953 (2015)

Category 2 substances are deemed by the FDA to have significant safety risks and compounding of those substances by503A pharmacies could result in FDA or state action

The GCLC floxed X CaMKII-Cre mouse was named here as GCLC-KO for the sake of convenience

J Eur Acad Dermatol Venereol 2010