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Regarding heme oxygenase 1 (Hmox1), its expression both at the RNA and protein levels showed a biphasic induction at 624 and 60 h (Figures 7a and b)

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References 13 (meta-analysis) and 14 (review) report that SFA consumption is not associated with an increased risk of incident diabetes but that replacing dietary carbohydrates and SFAs with PUFAs is linked to improved glycaemia and insulin sensitivity

Safety profile: No systemic toxicity was reported, and adverse effects were restricted to moderate transitory erythema in less than 5% of individuals

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It works by inhibiting the interaction between melanocytes and keratinocytes, which reduces the production of melanin, the pigment responsible for dark spots and uneven skin tone