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PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration

Cellular glutathione concentration has a significant effect as an antioxidant and varies in amount according to lifestyle and oxidative stress

Patients with rare genetic conditions affecting B12 metabolism are typically managed by specialists who may prescribe high-dose hydroxocobalamin

Li G, Ma R, Huang C, Tang Q , Fu Q , Liu H, et al

Because those with this mutation are already at higher risk of mental disorders, this is an important preventative measure

In brief, trypsinized cells were washed three times with PBS and lysed in lysis buffer (5 mM triethanolamine, 150 mM NaCl, 4% SDS, 2 units benzonase, 5 mM PMSF, pH 7.4) with protease inhibitor cocktail followed by adding EDTA to a final concentration of 5 mM