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do not crush or break them, as they are extended-release

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Many find this useful, as it helps to control hunger in the evening when cravings can often be stronger

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Allow a few minutes for full absorption before layering other products on top

The mobile phase comprised of (A) 10 mM ammonium formate in 60% aqueous acetonitrile containing 0.1% formic acid and (B) 10 mM ammonium formate in 9:1 mixture of isopropanol and acetonitrile with a 0.5 mL/min flow rate maintained during a 20 min run