6 January 2022
Treatment schedule When investigating the treatment regimen more frequently used in both groups, OW subcutaneous semaglutide was more commonly prescribed as first-step intensification therapy in add-on to metformin compared to oral semaglutide (36.7% versus 19.15% of patients, p = 0.0016), while oral semaglutide was recurrently used in case of failure of previous treatment (66% versus 42.9% of patients, p = 0.0001), and especially to replace a previous treatment regimen including a DPP4-inhibitor (26.95% versus 11.8% of patients, p = 0.0016) or a sulphonylureas (16.5% versus 6.2% of patients, p = 0.0057) or pioglitazone (3.5% versus 0% of patients, p = 0.012) (Fig
New England Journal of Medicine , 385(6), 503515
The authors suggest that differences in experimental design, dosing, or the specific animal models used may account for these mixed results
Tirzepatide belongs to a class of drugs known as incretin mimetics
This intelligence guides whether semaglutide, tirzepatide, GLP-Squared, or a microdose protocol offers your highest probability of success